Cystine/Glutamate Transporter Protein

Preferred Label : Cystine/Glutamate Transporter Protein;

NCIt synonyms : Cystine/Glutamate Transporter; Amino Acid Transport System xc-; Solute Carrier Family 7 Member 11; Calcium Channel Blocker Resistance Protein CCBR1; Cystine Glutamate Transporter Protein; System Xc(-) Transporter-Related Protein; XCT;

NCIt definition : Cystine/glutamate transporter protein (501aa, 55 kDa) is encoded by the human SLC7A11 gene. This protein is involved in the exchange of anionic amino acids and has a high specificity for anionic forms of cystine and glutamate. The protein has been identified as a method of entry utilized by the Karposi's sarcoma herpesvirus to gain entry into the cell. The virus plays an essential role in the pathogenesis of Karposi's sarcoma and certain types of lymphoma.;

Details

Origin ID

C61130;

UMLS CUI

C1880211;

OMIM relation
- Solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- SLC7A11 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Amino Acid Transporter [NCIt concept]
- Solute Carrier Family [NCIt concept]
- Viral Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Intracellular Transport [NCIt concept]
- Ligand Binding [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]
- Virus-Induced Membrane Fusion [NCIt concept]
is_target
- Fluorine F 18 Florilglutamic Acid [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients