Preferred Label : Fluorine F 18 Florilglutamic Acid;
NCIt synonyms : (4S)-(3-[F-18]fluoropropyl)-L-glutamic Acid; Fluorine F 18 L-glutamate Derivative BAY94-9392; (S)-4-(3-18F-fluoropropyl)-L-glutamic Acid;
NCIt related terms : FLORILGLUTAMIC ACID F-18;
NCIt definition : A radioconjugate composed of the radionuclide fluorine F 18 conjugated to the florilglutamic
acid that targets the cystine/glutamate transporter protein (xCT or SLC7A11), which
is a subunit of the transport system xc(-), with potential imaging activity upon positron
emission tomography (PET). Upon intravenous administration, fluorine F 18 florilglutamic
acid specifically binds to xCT and is subsequently taken up by the cell via xc(-).
Upon uptake, xc(-) activity can be assessed and tumor cells can be detected and imaged
by PET. System xc(-), a sodium-independent, heterodimeric transporter, mediates the
cellular uptake of cystine in exchange for intracellular glutamate at the plasma membrane;
although, it will take up glutamate as well. Xc(-) shows increased activity in certain
tumor cells compared to normal, healthy cells due to increased metabolic activity
in tumor cells; it plays a key role in tumor cell proliferation, progression and chemoresistance
as well as in the management of oxidative stress.;
UNII : 92T1Y5X038;
InChIKey : MKDNDKMECWBLOF-XUCPOOORSA-N;
CAS number : 1196963-74-2;
Molecule name : 18F-FSPG; BAY94-9392;
NCI Metathesaurus CUI : CL1406054;
Origin ID : C171885;
UMLS CUI : C4053691;
Semantic type(s)
- concept_is_in_subset
- has_target
