High Grade Prostatic Intraepithelial Neoplasia

Preferred Label : High Grade Prostatic Intraepithelial Neoplasia;

NCIt synonyms : High-Grade Intraepithelial Neoplasia of the Prostate; High-Grade Intraepithelial Neoplasia of Prostate; High-Grade PIN; HGPIN; High-Grade Prostatic Intraepithelial Neoplasia;

NCIt related terms : High-grade Prostatic Intraepithelial Neoplasia (PIN); Prostatic intraepithelial neoplasia (high grade);

NCIt definition : Prostatic intraepithelial neoplasia characterized by the presence of morphologically malignant cells lining the acini and ducts. The malignant cells are enlarged, contain prominent nucleoli, and have increased nuclear/cytoplasmic ratio. The malignant cells may grow within the ducts and acini in four architectural patterns: flat, tufting, micropapillary, and cribriform. The presence of high grade prostatic intraepithelial neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma on repeat biopsy.;

Neoplastic status : Undetermined;

Details

Origin ID

C5541;

UMLS CUI

C1168327;

Automatic exact mappings (from CISMeF team)
- High grade intraepithelial lesion of prostate [ICD-11 Subcategory]
- High grade prostatic intraepithelial neoplasia [LOINC component]
- Prostatic intraepithelial neoplasia high grade (disorder) [SNOMED CT concept]
- Prostatic intraepithelial neoplasia, grade III [ICD-11 Extension code]
- high grade prostatic intraepithelial neoplasia [Radlex concept]
CISMeF manual mappings
- High grade prostatic intraepithelial neoplasia (disorder) [SNOMED CT concept]
Currated CISMeF NLP mapping
- High grade prostatic intraepithelial neoplasia [MedDRA LLT]
Disease excludes abnormal cell
- Dysplastic Squamous Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Has associated anatomic sites
- Genitourinary System [NCIt concept]
- Male Reproductive System [NCIt concept]
- Prostate Gland [NCIt concept]
- Reproductive System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- High grade prostatic intraepithelial neoplasia [MedDRA LLT]
- High grade prostatic intraepithelial neoplasia [LOINC component]
- High grade prostatic intraepithelial neoplasia (disorder) [SNOMED CT concept]
- Prostatic intraepithelial neoplasia high grade (disorder) [SNOMED CT concept]
associated_with_malfunction_of_gene_product
- Histone-Arginine Methyltransferase CARM1 [NCIt concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Operational Ontology for Radiation Oncology Prostate Cancer Terminology [NCIt concept]
disease_excludes_finding
- Invasive Lesion [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Dysplastic Glandular Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_associated_gene
- CARM1 Gene [NCIt concept]
- CARM1 wt Allele [NCIt concept]
disease_has_finding
- Dysplasia [NCIt concept]
- Epithelial Component Present [NCIt concept]
disease_has_grade
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Glandular Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Glandular Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Prostate Gland [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 10 [NCIt concept]
- Gain of Chromosome 12 [NCIt concept]
- Gain of Chromosome 7 [NCIt concept]
- Gain of Chromosome 8q [NCIt concept]
- Gain of Chromosome Y [NCIt concept]
- Loss of Chromosome 10q [NCIt concept]
- Loss of Chromosome 16q [NCIt concept]
- Loss of Chromosome 18q [NCIt concept]
- Loss of Chromosome 8p [NCIt concept]
disease_may_have_molecular_abnormality
- MYC Gene Amplification [NCIt concept]
- PTEN Gene Inactivation [NCIt concept]
- TMPRSS2-ERG Fusion Protein Expression [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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