Preferred Label : high grade prostatic intraepithelial neoplasia;
RADLEX synonyms : high grade PIN; high grade intraepithelial neoplasia of prostate;
Definition : Prostatic intraepithelial neoplasia characterized by the presence of morphologically
malignant cells lining the acini and ducts. The malignant cells are enlarged, contain
prominent nucleoli, and have increased nuclear/cytoloplasmic ratio. The malignant
cells may grow within the ducts and acini in four architectural patterns: flat, tufting,
micropapillary, and cribriform. The presence of high grade prostatic intraepithelial
neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma
on repeat biopsy.;
RADLEX acronyms : HGPIN;
Source : PI-RADS;
Origin ID : RID49519;
Automatic exact mappings (from CISMeF team)
Prostatic intraepithelial neoplasia characterized by the presence of morphologically
malignant cells lining the acini and ducts. The malignant cells are enlarged, contain
prominent nucleoli, and have increased nuclear/cytoloplasmic ratio. The malignant
cells may grow within the ducts and acini in four architectural patterns: flat, tufting,
micropapillary, and cribriform. The presence of high grade prostatic intraepithelial
neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma
on repeat biopsy.
