FASTK wt Allele

Preferred Label : FASTK wt Allele;

NCIt synonyms : Fas-Activated Serine/Threonine Kinase wt Allele; FAST; FLJ13079;

NCIt definition : Human FASTK wild-type allele is located within 7q35 and is approximately 4 kb in length. This allele, which encodes Fas-activated serine/threonine kinase protein, is involved in apoptotic inhibition via a mechanism mediated by the translational silencer TIA-1.;

NCIt note : The FASTK gene product (FAST) may act as a sensor of mitochondrial stress that modulates a TIA-1-regulated post-transcriptional stress response program. The FASTK gene is expressed in the brain, heart, kidneys, liver, lungs, placenta, and skeletal muscle. This gene produces four RNA transcript variants which encode four corresponding protein isoforms.;

GenBank Accession Number : NM_006712;

Details

Origin ID

C51201;

UMLS CUI

C1705510;

Automatic exact mappings (from CISMeF team)
- Fas-activated serine/threonine kinase [OMIM gene]
- Fas-activated serine/threonine kinase activity [GO term]
- Fast (qualifier value) [SNOMED CT concept]
- Fasting [MedDRA Preferred Term]
- Fasting (finding) [SNOMED CT concept]
- Fasting (regime/therapy) [SNOMED CT concept]
- Not fasting (situation) [SNOMED CT concept]
- fasting [Artificial nutrition thesaurus concept]
- fasting [MeSH Descriptor]
- fasting [MeSH concept]
- rapid [Radlex concept]
- too fast [NCCMERP Descriptor]
- troponin T3, fast skeletal type [HGNC gene]
OMIM relation
- Fas-activated serine/threonine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 7: 150215599-150211356 [NCIt concept]
gene_in_chromosomal_location
- 7q35 [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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