Nitroglycerin - CISMeF

Preferred Label : Nitroglycerin;

NCIt definition : An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution.;

Alternative definition : NCI-GLOSS: In medicine, a substance used as a drug to treat certain heart conditions and to widen the openings in blood vessels. Nitroglycerin is being studied as a way to help chemotherapy work better by making tumor cells more sensitive to the drugs. It is a type of vasodilator.;

UNII : G59M7S0WS3;

InChIKey : SNIOPGDIGTZGOP-UHFFFAOYSA-N;

CAS number : 55-63-0;

Drug name : Rectiv;

Chemical formula : C3H5N3O9;

ChEBI ID : CHEBI:28787;

Codes from synonyms : CDR0000626334;

Details

Origin ID

C29294;

UMLS CUI

C0017887;

See also inter- (CISMeF)
- Product containing glyceryl trinitrate (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Glyceryl trinitrate (substance) [SNOMED CT concept]
- Nitroglycerin [LOINC component]
- Nitroglycerin, nitro-glycerol (medicinal) [ICD-11 Extension code]
- Product containing glyceryl trinitrate (medicinal product) [SNOMED CT concept]
- Trinitrine [ICD-11 Extension code]
- glycerol trinitrate [Substance BNPC]
- glyceryl trinitrate [ATC Code]
- glyceryl trinitrate [ATC Code]
- nitroglycerin [MeSH concept]
- nitroglycerin [SNOMED Notion]
- nitroglycerin [MeSH Descriptor]
Validated automatic mappings to BTNT
- glyceryl trinitrate [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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