Oxidized Purine Nucleoside Triphosphate Hydrolase

Preferred Label : Oxidized Purine Nucleoside Triphosphate Hydrolase;

NCIt synonyms : Nucleoside Diphosphate-Linked Moiety X Motif 1; Nudix Motif 1; 8-oxo-dGTPase; 2-Hydroxy-dATP Diphosphatase; EC 3.6.1.56; EC 3.6.1.55; Eight-oxo-dGTPase; NUDT1; 8-Oxo-7,8-Dihydrodeoxyguanosine Triphosphatase; 8-Oxo-7,8-Dihydroguanosine Triphosphatase; Nucleoside Diphosphate-Linked Moiety X-Type Motif 1; Methylated Purine Nucleoside Triphosphate Hydrolase; 7,8-Dihydro-8-Oxoguanine Triphosphatase;

NCIt definition : Oxidized purine nucleoside triphosphate hydrolase (197 aa, 23 kDa) is encoded by the human NUDT1 gene. This protein is involved in the metabolism of both dGTP and DNA.;

NCIt note : 7,8-dihydro-8-oxoguanine triphosphatase catalyzes the hydrolysis of 8-oxo-dGTP to yield 8-oxo-dGMP and diphosphate. Misincorporation of 8-oxo-dGTP into DNA can result in A:T to C:G transversion mutations.;

Details

Origin ID

C49206;

UMLS CUI

C1307127;

Automatic exact mappings (from CISMeF team)
- Nudix hydrolase 1 [OMIM gene]
- nudix hydrolase 1 [HGNC gene]
OMIM relation
- Nudix hydrolase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 8-oxodGTPase [MeSH concept]
- 8-oxodGTPase [MeSH Supplementary Concept]
- NUDT1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- NUDT1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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