8-oxodGTPase - CISMeF

Preferred Label : 8-oxodGTPase;

MeSH note : found in MutT protein of E coli & in humans; hydrolyzes 8-oxodGTP to 8-oxodGMP; also degrades dGTP & dATP to dGMP & dAMP, respectively; MW 18 kDa; prevents A.T to C.G transversion caused by 8-oxodGTP, which forms spontaneously in nucleotide pool of E coli; mutant form with Met replacing Val at position 83 may be antimutagenic for human cancer;

CISMeF synonym : NUDT1 protein, human;

MeSH synonym : 8-oxo-dGTPase; 8-oxo-deoxy-GTPase; 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase; 8-oxo-7,8-dihydroguanosine triphosphatase;

MeSH hyponym : MTH1 protein, human; MutT homolog 1 protein, human; nudix (nucleoside diphosphate linked moiety X)-type motif 1, human;

Registry Number MeSH : EC 3.1.6.-; EC 3.6.1.55;

Is substance : O;

UNII : EC 3.6.1.55;

Details

Origin ID

C078207;

UMLS CUI

C0210507;

Automatic exact mappings (from CISMeF team)
- Fanconi Anemia Group J Protein [NCIt concept]
- Fanconi Anemia Group M Protein [NCIt concept]
- General Transcription and DNA Repair Factor IIH Helicase Subunit XPD [NCIt concept]
- Nudix hydrolase 1 [OMIM gene]
- RNA Helicase [NCIt concept]
- TFIIH Basal Transcription Factor Complex Helicase XPB Subunit [NCIt concept]
- nudix hydrolase 1 [HGNC gene]
MeSH indexing information
- antimutagenic agents [MeSH Descriptor]
MeSH term(s) associated for indexing
- dna repair enzymes [MeSH Descriptor]
- phosphoric monoester hydrolases [MeSH Descriptor]
Record concept(s)
- 8-oxodGTPase [MeSH concept]
- NUDT1 protein, human [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Oxidized Purine Nucleoside Triphosphate Hydrolase [NCIt concept]

Keyword's position in hierarchy(ies) :

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