NCIt synonyms : SCC of the Mouth; SCC of Mouth; Squamous Cell Carcinoma of the Mouth; Mouth Squamous Cell Carcinoma; Squamous Cell Carcinoma of Mouth; Mouth SCC; Squamous Cell Carcinoma of Oral Cavity; Oral Cavity SCC; Squamous Cell Carcinoma of the Oral Cavity; SCC of Oral Cavity; SCC of the Oral Cavity; OSCC;
NCIt related terms : Oral Cavity Squamous Cell Cancer;
NCIt definition : A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults
in their fifth and sixth decades of life and is associated with alcohol and tobacco
use. Human papillomavirus is present in approximately half of the cases. It is characterized
by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients
are often asymptomatic. Physical examination may reveal erythematous or white lesions
or plaques. The majority of patients present with signs and symptoms of locally advanced
disease including mucosal ulceration, pain, difficulty with speaking, chewing, and
swallowing, bleeding, weight loss, and neck swelling. Patients may also present with
swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most
significant prognostic factors are the size of the tumor and the lymph nodes status.;