Protein Phosphatase 2A

Preferred Label : Protein Phosphatase 2A;

NCIt synonyms : PP2A; Protein Phosphatase 2A Complex;

NCIt definition : PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression.;

Details

Origin ID

C42582;

UMLS CUI

C1704708;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- protein phosphatase 2 [MeSH concept]
- protein phosphatase 2 [MeSH Descriptor]
gene_product_has_biochemical_function
- Phosphoprotein Phosphatase [NCIt concept]
has_gene_product_element
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 55 kDa Regulatory Subunit B Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Delta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Epsilon Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A Activator [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta [NCIt concept]

Keyword's position in hierarchy(ies) :

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