Wnt/LRP6 Signaling Pathway

Preferred Label : Wnt/LRP6 Signaling Pathway;

NCIt synonyms : Wnt LRP6 Signaling Pathway;

NCIt related terms : Wnt/LRP6 Signaling;

Alternative definition : BIOCARTA: Wnt glycoproteins play a role in diverse processes during embryonic patterning in metazoa through interaction with frizzled-type seven-transmembrane-domain receptors (Frz) to stabilize b-catenin. LDL-receptor-related protein 6 (LRP6), a Wnt co-receptor, is required for this interaction. Dikkopf (dkk) proteins are both positive and negative modulators of this signaling. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_wnt-lrp6Pathway;

Details

Origin ID

C39269;

UMLS CUI

C1520157;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Dickkopf-Related Protein 1 [NCIt concept]
- Dickkopf-Related Protein 2 [NCIt concept]
- Dickkopf-Related Protein 4 [NCIt concept]
- Frizzled-1 [NCIt concept]
- Low-Density Lipoprotein Receptor-Related Protein 6 [NCIt concept]
pathway_has_gene_element
- DKK1 wt Allele [NCIt concept]
- DKK2 wt Allele [NCIt concept]
- DKK4 wt Allele [NCIt concept]
- FZD1 wt Allele [NCIt concept]
- LRP6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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