Preferred Label : Reelin Signaling Pathway BioCarta;
NCIt related terms : Reelin Signaling Pathway;
Alternative definition : BIOCARTA: Reelin is an extracellular protein secreted by neurons. Reeler mice with
a defective Reelin gene exhibit neuronal abnormalities in development. Mice that are
heterozygous for the Reelin knockout have neuroanatomical and behavioral traits similar
to those of schizophrenia patients, suggesting that mice with a deficiency in Reelin
may provide a useful model for schizophrenia. Reelin protein may be involved in cognitive
function in adults as well as playing a role in the developmental organization of
neurons in the cortex. Multiple cell surface receptors transduce Reelin signaling
into neurons. One class of Reelin receptor includes the VLDL receptor and the ApoER2.
The intracellular adaptor Dab1 binds to the VLDL receptor and ApoER2 receptor through
an NPxY motif and is involved in transmission of Reelin signals through these lipoprotein
receptors. Mutation of the mDab1 gene in mice creates a phenotype identical to Reeler
mice, supporting the role of this cytoplasmic factor in signaling downstream from
Reelin. Another class of receptor for Reelin is the cadherin-related neuronal receptors,
CNR receptors. Reelin signaling through several different CNR receptors activates
the Fyn tyrosine kinases. Reelin stimulates phosphorylation of Dab1 and Dab1 appears
to link Reelin signaling with tyrosine kinases. Disruption of the p35 and Cdk5 genes
in mice indicates that cdk5 is also involved in the role of Reelin in neuronal development.
(This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_reelinPathway;
Origin ID : C39220;
UMLS CUI : C1514810;
Semantic type(s)
has_gene_product_element
pathway_has_gene_element