Adenosine Receptor A2b

Preferred Label : Adenosine Receptor A2b;

NCIt synonyms : ADORA2B; Adenosine A2B Receptor; ADORA2; Adenosine-A2B Receptor;

NCIt definition : Adenosine receptor A2b (332 aa, 36 kDa) is encoded by the human ADORA2B gene. This protein is involved in signaling and cellular defense.;

NCIt note : Encoded by human ADORA2B Gene (GPCR1 Family), 332-aa 360-kDa Adenosine A2B Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation. ADORA2B is also a Netrin-1 receptor in axon elongation, inducing cAMP accumulation. Netrin-1 also binds DCC, which interacts with ADORA2B as well; Netrin-1 growth-promotion may require a DCC/A2B receptor complex or act through DCC independently of ADORA2B. Cycling expression of clock gene Period-1 (rodent) depends on adenosine A2B receptor, which occurs through nocturnal activation of melatonin Mt1 receptors.; Protein_Plays_Role_In_Biological_Process: Axon Elongation;

Details

Origin ID

C38614;

UMLS CUI

C1527413;

Currated CISMeF NLP mapping
- receptor, adenosine A2B [MeSH concept]
- receptor, adenosine a2b [MeSH Descriptor]
OMIM relation
- Adenosine a2b receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ADORA2B protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ADORA2B Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Purinergic P1 Receptor [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Parkinson's Disease Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Defense Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein Kinase Protein Phosphorylation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- A2A/A2B Adenosine Receptor Antagonist INCB106385 [NCIt concept]
- Adenosine A2B Receptor Antagonist PBF-1129 [NCIt concept]
- Adenosine A2B Receptor Antagonist TT-4 [NCIt concept]
- Adenosine A2B Receptor Antagonist TT-702 [NCIt concept]
- Etrumadenant [NCIt concept]

Keyword's position in hierarchy(ies) :

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