" /> Adenosine Receptor A2b - CISMeF





Preferred Label : Adenosine Receptor A2b;

NCIt synonyms : ADORA2B; Adenosine A2B Receptor; ADORA2; Adenosine-A2B Receptor;

NCIt definition : Adenosine receptor A2b (332 aa, 36 kDa) is encoded by the human ADORA2B gene. This protein is involved in signaling and cellular defense.;

NCIt note : Encoded by human ADORA2B Gene (GPCR1 Family), 332-aa 360-kDa Adenosine A2B Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation. ADORA2B is also a Netrin-1 receptor in axon elongation, inducing cAMP accumulation. Netrin-1 also binds DCC, which interacts with ADORA2B as well; Netrin-1 growth-promotion may require a DCC/A2B receptor complex or act through DCC independently of ADORA2B. Cycling expression of clock gene Period-1 (rodent) depends on adenosine A2B receptor, which occurs through nocturnal activation of melatonin Mt1 receptors.; Protein_Plays_Role_In_Biological_Process: Axon Elongation;

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30/07/2025


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