Myelodysplastic Syndrome

Preferred Label : Myelodysplastic Syndrome;

NCIt synonyms : Oligoblastic Leukemia; Myelodysplastic Neoplasm; Myelodysplasia; MDN; Myelodysplastic Syndrome/Neoplasm; MDS; Dysmyelopoietic Syndrome;

NCIt related terms : smoldering leukemia; myelodysplastic syndromes; Preleukemia;

NCIt definition : A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001);

Alternative definition : CTCAE: A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.; NICHD: A pre-malignant disorder characterized by blood cytopenias and abnormalities in bone marrow morphology.; NCI-GLOSS: A group of diseases in which the bone marrow does not make enough healthy blood cells.;

Neoplastic status : Malignant;

ICD-O code : 9989/3;

Codes from synonyms : CDR0000045480; CDR0000045953; E12552; CDR0000046583; CDR0000045266;

Details

Origin ID

C3247;

UMLS CUI

C3463824;

Currated CISMeF NLP mapping
- MYELODYSPLASTIC SYNDROME [WHO-ART Included Term]
- MYELOID DYSPLASIA [WHO-ART Preferred Term]
- Myelodysplasia [HPO term]
- Myelodysplasia [MedDRA LLT]
- Myelodysplastic syndrome [PASCAL descriptor]
- Myelodysplastic syndrome [HPO term]
- Myelodysplastic syndrome [MedDRA Preferred Term]
- Myelodysplastic syndrome [OMIM Phenotype]
- Myelodysplastic syndrome [ORDO Disease]
- Myelodysplastic syndrome [HRDO Sign]
- Myelodysplastic syndrome NOS [MedDRA LLT]
- Myelodysplastic syndrome, NOS [ICD-O code]
- Myelodysplastic syndrome, NOS [ICD-11 Extension code]
- Myelodysplastic syndrome, unclassifiable [ICD-11 Category]
- Myelodysplastic syndromes [ICD-10 category]
- Myelodysplastic syndromes [Bloc CIM-11]
- Myelodysplastic syndromes [Bloc CIM-11]
- Myelodysplastic syndromes [ICD-10 category (who)]
- Myelodysplastic syndromes [MedDRA High Level Term]
- Preleukaemia [MedDRA LLT]
- Preleukemia [MedDRA LLT]
- myelodysplasia [SNOMED Notion]
- myelodysplastic syndrome [DO Concept]
- myelodysplastic syndrome [Disease (Nov.)]
- myelodysplastic syndrome [Blood Transfusion thesaurus concept]
- myelodysplastic syndromes [MedlinePlus Topic]
- myelodysplastic syndromes [MeSH Descriptor]
- myelodysplastic syndromes [MeSH concept]
- preleukemia [MeSH Descriptor]
- preleukemia [MeSH concept]
- refractory anemia [ICD-O menu]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
False automatic mappings
- Myelodysplastic neoplasm (morphologic abnormality) [SNOMED CT concept]
- Myelodysplastic syndrome (disorder) [SNOMED CT concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
See also inter- (CISMeF)
- preleukemia [Disease (Nov.)]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- MYELODYSPLASTIC SYNDROME [WHO-ART Included Term]
- MYELOID DYSPLASIA [WHO-ART Preferred Term]
- Myelodysplasia [HPO term]
- Myelodysplasia [MedDRA LLT]
- Myelodysplastic neoplasm (morphologic abnormality) [SNOMED CT concept]
- Myelodysplastic syndrome [MedDRA Preferred Term]
- Myelodysplastic syndrome [OMIM Phenotype]
- Myelodysplastic syndrome [ORDO Disease]
- Myelodysplastic syndrome [HRDO Sign]
- Myelodysplastic syndrome (disorder) [SNOMED CT concept]
- Myelodysplastic syndrome NOS [MedDRA LLT]
- Myelodysplastic syndrome, unspecified [ICD-10 Sub-category]
- Myelodysplastic syndrome, unspecified [ICD-9 code]
- Myelodysplastic syndromes [ICD-10 category]
- Myelodysplastic syndromes [MedDRA High Level Term]
- Myelodysplastic syndromes [Bloc CIM-11]
- Myeloid dysplasia [MedDRA LLT]
- Preleukaemia [MedDRA LLT]
- Preleukemia [MedDRA LLT]
- myelodysplastic syndrome [Disease (Nov.)]
- myelodysplastic syndromes [MeSH Descriptor]
- myelodysplastic syndromes [MedlinePlus Topic]
Validated automatic mappings to BTNT
- refractory anemia with excess blasts [Disease (Nov.)]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Adverse Events Terminology [NCIt concept]
- Pediatric Adverse Events Terminology Mapped to MedDRA [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_associated_disease
- Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome [NCIt concept]
disease_has_associated_gene
- NPM1 Gene [NCIt concept]
- NPM1 wt Allele [NCIt concept]
- NUP214 Gene [NCIt concept]
- NUP214 wt Allele [NCIt concept]
- PURA Gene [NCIt concept]
- PURA wt Allele [NCIt concept]
- TEC Gene [NCIt concept]
- TEC wt Allele [NCIt concept]
disease_has_finding
- Bone Marrow Dysplasia Present [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Myeloblasts Under 20 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Myeloblasts Under 20 Percent of Peripheral Blood White Cells [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
human_disease_maps_to_eo_disease
- Mouse Myelodysplastic Syndrome [NCIt concept]
may_be_associated_disease_of_disease
- Fanconi Anemia [NCIt concept]
- Fanconi Anemia, Complementation Group A [NCIt concept]
- Fanconi Anemia, Complementation Group B [NCIt concept]
- Fanconi Anemia, Complementation Group C [NCIt concept]
- Fanconi Anemia, Complementation Group D1 [NCIt concept]
- Fanconi Anemia, Complementation Group D2 [NCIt concept]
- Fanconi Anemia, Complementation Group E [NCIt concept]
- Fanconi Anemia, Complementation Group F [NCIt concept]
- Fanconi Anemia, Complementation Group G [NCIt concept]
- Fanconi Anemia, Complementation Group I [NCIt concept]
- Fanconi Anemia, Complementation Group J [NCIt concept]
- Fanconi Anemia, Complementation Group L [NCIt concept]
- Fanconi Anemia, Complementation Group N [NCIt concept]
- Fanconi Anemia, Complementation Group O [NCIt concept]

Keyword's position in hierarchy(ies) :

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