Thyrotropin Receptor

Preferred Label : Thyrotropin Receptor;

NCIt synonyms : TSHR; Thyroid Stimulating Hormone Receptor; hTSHR-I; TSH-R; Thyrotropin Receptor-I;

NCIt related terms : Thyroid-Stimulating Hormone Receptor; TSH Receptor;

NCIt definition : Thyrotropin receptor (764 aa, 87 kDa) is encoded by the human TSHR gene. This protein is involved in thyrotropin- and thyrostimulin-dependent G protein-coupled receptor signaling and the regulation of thyroid function.;

Alternative definition : CDISC: An antigen encoded by the TSHR gene that responds to thyroid-stimulating hormone and is involved in the regulation of thyroid function. It can be considered as an autoantigen and is commonly associated with autoimmune thyroid diseases.;

Details

Origin ID

C30133;

UMLS CUI

C4281796;

Currated CISMeF NLP mapping
- Thyrotropin receptor (substance) [SNOMED CT concept]
- receptors, thyrotropin [MeSH Descriptor]
- receptors, thyrotropin [MeSH concept]
- thyrotropin receptor site [SNOMED Notion]
False automatic mappings
- thyrotropin receptor (256-275) [MeSH concept]
- thyrotropin receptor (256-275) [MeSH Supplementary Concept]
OMIM relation
- Thyroid-stimulating hormone receptor [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TSHR Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
- Thyroid Gland Tissue [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Recombinant Thyrotropin Alfa [NCIt concept]

Keyword's position in hierarchy(ies) :

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