Protein SET - CISMeF

Preferred Label : Protein SET;

NCIt synonyms : HLA-DR Associated Protein II; I-2PP2A; SET; IGAAD; PHAPII; SET Protein; 2PP2A; TAF-I; Template Activating Factor I Beta; SET Translocation Inhibitor-2 of Protein Phosphatase-2A; Phosphatase 2A Inhibitor I2PP2A; I2PP2A; Inhibitor of Granzyme A-Activated DNase; Inhibitor of GZMA-Activated DNase; Template-Activating Factor I; TAF-IBeta; Phosphatase-2A Inhibitor-I2PP2A;

NCIt definition : Protein SET (290 aa, 33 kDa) is encoded by the human SET gene. This protein is involved in the modulation of apoptosis, transcription, and nucleosome assembly.;

NCIt note : Protein SET is a specific inhibitor of PP2A that may be involved in intracellular signaling after ligand activation of HLA class II molecules. Serine phosphorylated SET has a long acidic C-terminus and SET domain. SET is a specific inhibitor of GZMA-activated DNase/nucleoside diphosphate kinase (GAAD/NM23H1). GZMA cleavage of SET releases NM23H1 from inhibition, results in SET degradation, NM23H1 translocation to the nucleus, and NM23H1 nicking of DNA.;

Details

Origin ID

C29939;

UMLS CUI

C1137947;

Automatic exact mappings (from CISMeF team)
- Carboxypeptidase B2 [MeSH Descriptor]
- Carboxypeptidase b2, plasma [OMIM gene]
- Immunoglobulin A deficiency [ORDO Disease]
- SET nuclear proto-oncogene [ORDO Gene]
- SET nuclear proto-oncogene [HGNC gene]
- Set [LOINC Challenge]
- Set nuclear protooncogene [OMIM gene]
- curli [GO term]
- single-electron transfer mechanism [IUPAC Term]
Currated CISMeF NLP mapping
- {Setting} [LOINC System]
False automatic mappings
- Set [LOINC System]
- Set, Psychology [MeSH Descriptor]
- Set, Psychology [MeSH concept]
- setting [PSIP Taxonomy Axis]
- setting (of initial error) [NCCMERP Class]
- setting (where error perpetuated) [NCCMERP Class]
OMIM relation
- Set nuclear protooncogene [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SET protein, human [MeSH concept]
- SET protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SET Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Granzyme A Mediated Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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