Diclofenac - CISMeF

Preferred Label : Diclofenac;

NCIt synonyms : 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid;

NCIt definition : A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04);

Alternative definition : NCI-GLOSS: The active ingredient in a drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent.;

UNII : 144O8QL0L1;

InChIKey : DCOPUUMXTXDBNB-UHFFFAOYSA-N;

CAS number : 15307-86-5;

Chemical formula : C14H11Cl2NO2;

ChEBI ID : CHEBI:47381;

Codes from synonyms : CDR0000617659;

Details

Origin ID

C28985;

UMLS CUI

C0012091;

See also inter- (CISMeF)
- Product containing diclofenac (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Diclofenac [ICD-11 Extension code]
- Diclofenac [LOINC component]
- Diclofenac (substance) [SNOMED CT concept]
- Product containing diclofenac (medicinal product) [SNOMED CT concept]
- diclofenac [ATC Code]
- diclofenac [ATC Code]
- diclofenac [ATC Code]
- diclofenac [ATC Code]
- diclofenac [Substance BNPC]
- diclofenac [MeSH concept]
- diclofenac [SNOMED Notion]
- diclofenac [MeSH Descriptor]
Validated automatic mappings to BTNT
- diclofenac [ATC Code]
- diclofenac [ATC Code]
- diclofenac [ATC Code]
- diclofenac [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2C9 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Diclofenac Potassium [NCIt concept]
- Diclofenac Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Diclofenac Potassium [NCIt concept]
- Diclofenac Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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