Activin Receptor Type-1B

Preferred Label : Activin Receptor Type-1B;

NCIt synonyms : Activin Receptor-Like Kinase 4; Activin A Receptor, Type II-Like Kinase 4; Serine/Threonine-Protein Kinase Receptor R2; SKR2; ACTR-IB; ALK-4; Activin Receptor Type IB; Activin A Type IB Receptor; EC 2.7.11.30; Activin-A Type-B Receptor;

NCIt definition : Activin receptor type-1B (505 aa, 57 kDa) is encoded by the human ACVR1B gene. This protein plays a role in protein phosphorylation, signal transduction, cell cycle regulation and apoptosis.;

NCIt note : Type I receptors are essential for transmembrane signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.;

Details

Origin ID

C28714;

UMLS CUI

C0663443;

OMIM relation
- Activin a receptor, type ib [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ACVR1B protein, human [MeSH concept]
- ACVR1B protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ACVR1B Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Kidney [NCIt concept]
- Liver [NCIt concept]
- Lung [NCIt concept]
- Pancreas [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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