Macrophage Migration Inhibitory Factor

Preferred Label : Macrophage Migration Inhibitory Factor;

NCIt synonyms : Glycosylation-Inhibiting Factor; Phenylpyruvate Tautomerase; MIF; L-Dopachrome Tautomerase; EC 5.3.3.12; EC 5.3.2.1; L-Dopachrome Isomerase;

NCIt definition : Macrophage migration inhibitory factor (115 aa, 12 kDa) is encoded by the human MIF gene. This protein is involved in the regulation of the innate immune response.;

NCIt note : It is not clear whether the tautomerase activity of macrophage migration inhibitory factor has any physiological relevance. (UniProt);

Details

Origin ID

C28467;

UMLS CUI

C1870471;

False automatic mappings
- Melanocyte hormone inhibiting factor (substance) [SNOMED CT concept]
OMIM relation
- Macrophage migration inhibitory factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MIF protein, human [MeSH concept]
- MIF protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
- MIF Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Lymphokine [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Phenylalanine Metabolism Pathway [NCIt concept]
- Tyrosine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell-Mediated Immunity [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
is_target
- Imalumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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