Preferred Label : Imalumab;
NCIt synonyms : Immunoglobulin G1-kappa, Anti-(Homo sapiens MIF (Macrophage Migration Inhibitory Factor,
Glycosylation-inhibiting Factor, GlIF, GIF)), Homo sapiens Monoclonal Antibody;
NCIt definition : A human, recombinant monoclonal antibody (MoAb) against macrophage migration inhibitory
factor (MIF), with potential immunomodulating, anti-inflammatory and antineoplastic
activities. Upon intravenous administration, imalumab binds to MIF, blocking its activity
and preventing the MIF-mediated secretion of certain cytokines, including interleukin-1
beta and tumor necrosis factor-alpha. This may lead to an inhibition of cancer cell
proliferation in MIF-overexpressing tumor cells. MIF, a pro-inflammatory cytokine
overexpressed in some cancers, plays a key role in inflammation, immune responses
and cancer cell proliferation.;
UNII : 22F97PC79G;
CAS number : 1430205-07-4;
Molecule name : BAX069; BAX-69;
NCI Metathesaurus CUI : CL446652;
Origin ID : C104260;
UMLS CUI : C4053694;
Currated CISMeF NLP mapping
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
