Preferred Label : MIF Inhibitor IPG1094;
NCIt synonyms : MIF Tautomerase Inhibitor IPG1094;
NCIt definition : An orally bioavailable inhibitor of the pro-inflammatory cytokine macrophage migration
inhibitory factor (MIF), with potential anti-inflammatory, immunomodulating and antineoplastic
activities. Upon oral administration, MIF inhibitor IPG1094 targets, binds to and
inhibits the tautomerase activity of MIF. This attenuates the differentiation and
infiltration of the immunosuppressive monocytic myeloid-derived suppressor cells (MDSCs)
in the tumor microenvironment (TME), which results in an enhanced immune response
against tumor cells and the inhibition of tumor cell proliferation. MIF, overexpressed
in some cancers, plays a key role in inflammation, regulation of the immune response
and cancer cell proliferation. IPG1094 is able to penetrate the blood-brain barrier
(BBB).;
Molecule name : IPG-1094; IPG 1094;
NCI Metathesaurus CUI : CL1928597;
Origin ID : C206267;
concept_is_in_subset
- has_target
