Pirfenidone - CISMeF

Preferred Label : Pirfenidone;

NCIt definition : An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the prevention and treatment of scar tissue caused by radiation therapy. It belongs to the family of drugs called anti-inflammatory agents.;

UNII : D7NLD2JX7U;

InChIKey : ISWRGOKTTBVCFA-UHFFFAOYSA-N;

CAS number : 53179-13-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 53179-13-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C12H11NO;

Codes from synonyms : CDR0000045030;

Details

Origin ID

C2635;

UMLS CUI

C0298067;

Automatic exact mappings (from CISMeF team)
- Pirfenidone [ICD-11 Extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pirfenidone (substance) [SNOMED CT concept]
- Product containing pirfenidone (medicinal product) [SNOMED CT concept]
- pirfenidone [ATC Code]
- pirfenidone [MeSH Supplementary Concept]
- pirfenidone [MeSH concept]
Validated automatic mappings to BTNT
- pirfenidone [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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