Leukotriene B4 Receptor 1

Preferred Label : Leukotriene B4 Receptor 1;

NCIt synonyms : Chemoattractant Receptor-Like 1; Chemokine Receptor-Like 1; P2Y Purinoceptor 7; G Protein-Coupled Receptor 16; LTB4R; Purinoceptor P2Y7; Leukotriene B4 G Protein-Coupled Receptor; LTB4-R1; G-Protein Coupled Receptor 16; LTB4-R 1; P2Y7; Leukotriene B4 Receptor; Leukotriene-B4 Receptor;

NCIt definition : .Leukotriene B4 receptor 1 (352 aa, 38 kDa) is encoded by the human LTB4R gene. This protein is involved in both purine nucleotide binding and G protein-coupled receptor signaling.;

NCIt note : Leukotriene B4 Receptor, encoded by the LTB4R gene, belongs to family 1 of G-protein coupled receptors. This protein is a receptor for extracellular ATP, UTP and ADP, and its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. This protein may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. It is also a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. It is expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver, with high level of expression in lymphoid tissues. (SwissProt);

Details

Origin ID

C26329;

UMLS CUI

C1307920;

Currated CISMeF NLP mapping
- receptors, leukotriene B4 [MeSH concept]
- receptors, leukotriene b4 [MeSH Descriptor]
OMIM relation
- Leukotriene b4 receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- LTB4R protein, human [MeSH concept]
- LTB4R protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- LTB4R Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Heart [NCIt concept]
- Liver [NCIt concept]
- Lymphoid Tissue [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Leukotriene Receptor Family [NCIt concept]
- Purinergic Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cardiac Muscle Contraction [NCIt concept]
- Cell Motility [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immune Response Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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