" /> Rosiglitazone Maleate - CISMeF





Preferred Label : Rosiglitazone Maleate;

NCIt synonyms : ( /-)-5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, ( Z )-2-Butenedioate (1:1); Rosiglitazone;

NCIt related terms : Avandia;

NCIt definition : The maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.;

Alternative definition : NCI-GLOSS: A drug that helps control the amount of glucose (sugar) in the blood and is being studied in the prevention and treatment of some types of cancer. Avandia stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of thiazolidinedione and a type of antiangiogenesis agent.;

UNII : KX2339DP44;

InChIKey : SUFUKZSWUHZXAV-BTJKTKAUSA-N;

CAS number : 155141-29-0;

Drug name : Avandia;

Molecule name : BRL49653;

Chemical formula : C18H19N3O3S.C4H4O4;

NSC code : 717764;

ChEBI ID : CHEBI:8892;

Codes from synonyms : CDR0000601483; CDR0000601484; NSC0717764; 20342;

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22/05/2025


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