Rosiglitazone - CISMeF

Preferred Label : Rosiglitazone;

NCIt synonyms : Rosiglitazone Base;

NCIt definition : An agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. In addition to its selective affinity for peroxisome proliferator-activated receptor (PPAR) gamma and its ability to lower blood glucose levels, rosiglitazone also exerts anti-inflammatory activity through its ability to inhibit nuclear factor-kappaB (NF-KB) activity and increase I-kappaB levels. In addition, rosiglitazone may cause fluid retention and may worsen congestive heart failure. This agent is also associated with an increased risk of heart attacks.;

Alternative definition : NCI-GLOSS: The active ingredient in a drug that helps control the amount of glucose (sugar) in the blood and is being studied in the prevention and treatment of some types of cancer. Rosiglitazone stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of thiazolidinedione and a type of antiangiogenesis agent.;

UNII : 05V02F2KDG;

InChIKey : YASAKCUCGLMORW-UHFFFAOYSA-N;

CAS number : 122320-73-4;

Chemical formula : C18H19N3O3S;

ChEBI ID : CHEBI:50122;

Codes from synonyms : CDR0000044856;

Details

Origin ID

C62076;

UMLS CUI

C0289313;

Automatic exact mappings (from CISMeF team)
- Rosiglitazone [ICD-11 Extension code]
See also inter- (CISMeF)
- Product containing rosiglitazone (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing rosiglitazone (medicinal product) [SNOMED CT concept]
- Rosiglitazone [MeSH Descriptor]
- Rosiglitazone [LOINC component]
- Rosiglitazone (substance) [SNOMED CT concept]
- rosiglitazone [ATC Code]
- rosiglitazone [Substance BNPC]
- rosiglitazone [MeSH concept]
Validated automatic mappings to BTNT
- rosiglitazone [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Rosiglitazone Maleate [NCIt concept]
has_target
- Peroxisome Proliferator-Activated Receptor Gamma [NCIt concept]
is_free_acid_or_base_form_of
- Rosiglitazone Maleate [NCIt concept]

Keyword's position in hierarchy(ies) :

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