Preferred Label : MUC-1 Antigen;
NCIt synonyms : Mucin Antigen; Episialin; Cancer Antigen 15-3; DF3 Antigen; CA15-3 Antigen; Polymorphic Epithelial Mucin; Sialylated MUC-1; MAM-6; MUC-1; Mucin Peptide MUC-1;
NCIt related terms : mucin/peptide;
NCIt definition : MUC-1 antigen is a mammary-type apomucin, a high molecular weight transmembrane glycoprotein,
of which the extracellular domain is formed by a repeating 20 amino acid sequence
(in tandem) with a high content of serine and threonine on which are O-linked carbohydrate
chains. MUC-1 synthesis and secretion are features of glandular epithelial tissues;
MUC-1 is overexpressed in lactating breast and in breast, ovary, lung, and prostate
malignancies.;
Alternative definition : NCI-GLOSS: A substance found on certain epithelial cells (cells that cover organs,
glands, and other body surfaces) and on breast cells involved in making milk. It is
also found on tumors of the breast, ovary, lung, and prostate. MUC-1 is a type of
tumor marker.;
Codes from synonyms : CDR0000561236; CDR0000046273;
Origin ID : C2407;
UMLS CUI : C0006611;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
- is_target
- related_to_genetic_biomarker
