Preferred Label : Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1;
NCIt synonyms : P-MUC1C-ALLO1 CAR-T Cells; Allogeneic Anti-MUC1-C CAR T Cells P-MUC1C-ALLO1;
NCIt definition : An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes containing primarily
stem cell memory T-cells (Tscm) that have been genetically modified to express a chimeric
antigen receptor (CAR) specific for the C-terminal subunit of the tumor-associated
antigen (TAA) mucin-1 (MUC1-C) and gene-edited to knockout both the T-cell receptor
(TCR) and major histocompatibility complex (MHC) class I proteins, with potential
immunostimulating and antineoplastic activities. Upon administration, allogeneic MUC1-C-specific
CAR-T cells P-MUC1C-ALLO1 specifically recognize and induce selective toxicity in
MUC1-C-expressing tumor cells. MUC1, a glycoprotein normally expressed on epithelial
cells and overexpressed on the surface of a variety of cancer cells, plays a key role
in tumor cell survival and proliferation. The proteolytic cleavage of MUC1 in the
tumor microenvironment (TME) leads to the overexpression of MUC1-C in the TME.;
Molecule name : P-MUC1C-ALLO-1; P-MUC1C-ALLO 1;
NCI Metathesaurus CUI : CL1779239;
Origin ID : C187029;
UMLS CUI : C5667089;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
