Gastrin-Releasing Peptide

Preferred Label : Gastrin-Releasing Peptide;

NCIt synonyms : Mammalian Bombesin; GRP; Gastrin Releasing Peptide;

NCIt definition : Gastrin-releasing peptide (27 aa, 3 kDa) is encoded by the human GRP gene. This protein is involved in hormone signaling in both the gastrointestinal and nervous systems.;

NCIt note : Gastrin-releasing peptide is comprised of amino acids 24-50 of pre-progastrin-releasing peptide.; Gastrin-releasing peptide (GRP) is the equivalent in mammals of the amphibian bombesin. Infusion of either GRP or bombesin increases plasma levels of gastrin, pancreatic polypeptide, glucagon, gastric inhibitory peptide, and insulin. It is widely distributed in the gastrointestinal tract and in the nervous system. In normal adult mammal GRP is strictly a neuropeptide and functions in a neurotransmitter-like fashion. In the fetus, a larger form of GRP acts as a hormone and exerts growth factor-like activity on many organs, aiding in development.;

Details

Origin ID

C2272;

UMLS CUI

C2353852;

Automatic exact mappings (from CISMeF team)
- Galectin-like protein [OMIM gene]
- Gastrin-releasing peptide [OMIM gene]
- O-beta-ribosyl(1''-2')-guanosine-5''-phosphate [MeSH Supplementary Concept]
- gastrin releasing peptide [HGNC gene]
Currated CISMeF NLP mapping
- Gastrin-Releasing peptide [MeSH concept]
- Gastrin-releasing peptide (substance) [SNOMED CT concept]
- gastrin releasing peptide [SNOMED Notion]
- gastrin-releasing peptide [Artificial nutrition thesaurus concept]
- gastrin-releasing peptide [MeSH Descriptor]
False automatic mappings
- gastrin releasing peptide (1-16) [MeSH concept]
- gastrin releasing peptide (1-16) [MeSH Supplementary Concept]
- gastrin releasing peptide (14-27) [MeSH concept]
- gastrin releasing peptide (14-27) [MeSH Supplementary Concept]
- gastrin releasing peptide (21-27) [MeSH concept]
- gastrin releasing peptide (21-27) [MeSH Supplementary Concept]
OMIM relation
- Gastrin-releasing peptide [OMIM gene]
See also inter- (CISMeF)
- Gastrin releasing polypeptide [LOINC component]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Gastrin releasing polypeptide [LOINC component]
- Gastrin-Releasing peptide [MeSH concept]
- Gastrin-releasing peptide (substance) [SNOMED CT concept]
- gastrin releasing peptide [SNOMED Notion]
- gastrin-releasing peptide [MeSH Descriptor]
- ucma protein, human [MeSH Supplementary Concept]
- ucma protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- GRP Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- MoAb Bombesin (DTPA) [NCIt concept]
- MoAb Bombesin (ITC-D) [NCIt concept]
- Monoclonal Antibody 2A11 [NCIt concept]
gene_product_has_biochemical_function
- Neuropeptide [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Digestion [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Protein Secretion [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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