Monoclonal Antibody 2A11

Preferred Label : Monoclonal Antibody 2A11;

NCIt synonyms : MOAB Bombesin; MOAB BOMBESIN 2A11;

NCIt definition : A recombinant, murine monoclonal antibody directed against gastrin-releasing peptide, one of a number of bombesin-like peptides (BLP). Tumor cells, such as small cell lung cancer (SCLC) cells, express and secrete BLP that activate specific cell growth-promoting receptors. Monoclonal antibody 2A11 has been shown to decrease the growth of SCLC cells in vitro and in animal models. (NCI04);

Details

Origin ID

C29211;

UMLS CUI

C1518134;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Gastrin-Releasing Peptide [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]

Keyword's position in hierarchy(ies) :

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