Cysteinyl Leukotriene Receptor 1

Preferred Label : Cysteinyl Leukotriene Receptor 1;

NCIt synonyms : CysLT(1); HMTMF81; Cysteinyl Leukotriene D4 Receptor; CysLTR1; G-Protein Coupled Receptor HG55; LTD4 Receptor;

NCIt definition : Cysteinyl leukotriene receptor 1 (337 aa, 39 kDa) is encoded by the human CYSLTR1 gene. This protein plays a role in leukotriene binding and downstream signaling that regulates eosinophil migration and the proliferation and contraction of bronchial smooth muscle cells.;

NCIt note : Cysteinyl leukotriene receptor 1 ligands include the cysteinyl leukotrienes (in order of lowest to highest binding affinity): LTB4, LTC4, LTE4 and LTD4.;

Details

Origin ID

C215843;

OMIM relation
- Cysteinyl leukotriene receptor 1 [OMIM gene]
gene_encodes_gene_product
- CYSLTR1 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Smooth Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Alveolar Macrophage [NCIt concept]
- Leukocyte [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Leukotriene Receptor Family [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Endothelin Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Bronchoconstriction [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Leukotriene Activity Induction [NCIt concept]
- Leukotriene Receptor Binding [NCIt concept]
- Ligand Binding [NCIt concept]
- Lipid Binding [NCIt concept]
- Muscle Contraction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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