Calcium-Activated Chloride Channel Regulator 2

Preferred Label : Calcium-Activated Chloride Channel Regulator 2;

NCIt synonyms : CLCA2; Chloride Channel, Calcium Activated, Family Member 2 Protein; Calcium-Sensitive Chloride Channel 2; Calcium-Activated Chloride Channel-2; EC 3.4.-.-; Calcium-Activated Chloride Channel Protein 3; hCaCC-3; hCLCA2; CaCC-3; Calcium-Activated Chloride Channel Family Member 2;

NCIt definition : Calcium-activated chloride channel regulator 2 (943 aa, 104 kDa) is encoded by the human CLCA2 gene. This protein is involved in chloride ion transport.;

NCIt note : Calcium-activated chloride channel regulator 2 is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.;

Details

Origin ID

C21517;

UMLS CUI

C1447742;

Automatic exact mappings (from CISMeF team)
- Chloride channel accessory 2 [OMIM gene]
OMIM relation
- Chloride channel accessory 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CLCA2 protein, human [MeSH concept]
- CLCA2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- CLCA2 Gene [NCIt concept]
- Ion Channel Protein Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Lung [NCIt concept]
- Mammary Gland [NCIt concept]
- Trachea [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Ion Channel [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Olfactory Transduction Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Cystic Fibrosis [NCIt concept]
gene_product_plays_role_in_biological_process
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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