Activator of Apoptosis Harakiri

Preferred Label : Activator of Apoptosis Harakiri;

NCIt synonyms : Neuronal Death Protein DP5; BH3-Interacting Domain-Containing Protein 3; Harakiri; Activator of Apoptosis HRK; HRK; HRK Protein;

NCIt definition : Activator of apoptosis harakiri (91 aa, 10 kDa) is encoded by the human HRK gene. This protein is involved in the activation of apoptosis.;

NCIt note : Hrk is a protein promoting cell death by apoptosis. Hrk physically interacts with the survival-promoting proteins bcl-2 and bcl-xL, which also block cell death induced by expression of Hrk. Hrk does not interact with death-promoting proteins Bax or Bak.;

Details

Origin ID

C21206;

UMLS CUI

C0538571;

OMIM relation
- Harakiri [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HRK protein, human [MeSH Supplementary Concept]
- HRK protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- HRK Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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