MRE11/RAD50 Double-Strand Break Repair Complex

Preferred Label : MRE11/RAD50 Double-Strand Break Repair Complex;

NCIt synonyms : MRE11-RAD50 Double-Strand Break Repair Complex;

NCIt definition : The MRE11/RAD50 double-strand break repair complex consists of 5 proteins: Nibrin, p200, p400, MRE11, and RAD50. This complex possesses manganese-dependent single-stranded DNA endonuclease and 3-prime to 5-prime exonuclease activities. In mammalian cells, this complex is important for double-strand break repair, meiotic recombination, and telomere maintenance. It functions in diverse aspects of the cellular response to double strand breaks (DSBs), including the detection of DNA damage, the activation of cell cycle checkpoints, and DSB repair. (from OMIM);

Details

Origin ID

C21177;

UMLS CUI

C1334529;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Double Strand Break Repair [NCIt concept]
- Meiotic Recombination [NCIt concept]
- Telomere Maintenance [NCIt concept]
has_gene_product_element
- DNA Repair Protein RAD50 [NCIt concept]
- Double-Strand Break Repair Protein MRE11 [NCIt concept]
- Nibrin [NCIt concept]

Keyword's position in hierarchy(ies) :

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