NPC Intracellular Cholesterol Transporter 1

Preferred Label : NPC Intracellular Cholesterol Transporter 1;

NCIt synonyms : NPC1; Niemann-Pick C1 Protein;

NCIt definition : NPC intracellular cholesterol transporter 1 (1278 aa, 142 kDa) is encoded by the human NPC1 gene. This protein plays a role in the export of cholesterol from the endosomal/lysosomal compartment.;

NCIt note : NPC intracellular cholesterol transporter 1 acts as an endosomal entry receptor for ebolavirus. (UniProt); Cholesterol released from LDLs in late endosomes or lysosomes is transferred by NPC intracellular cholesterol transporter 2 to the cholesterol-binding pocket in the N-terminal domain of NPC intracellular cholesterol transporter 1. (UniProt);

Détails

Origin ID

C203992;

UMLS CUI

C0540824;

OMIM relation
- Npc intracellular cholesterol transporter 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NPC1 protein, human [MeSH Supplementary Concept]
- NPC1 protein, human [MeSH concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- NPC1 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Late Endosome [NCIt concept]
- Membrane of the Endosome [NCIt concept]
- Membrane of the Lysosome [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Solute Carrier Family [NCIt concept]
- Viral Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Autophagy [NCIt concept]
- Cholesterol Homeostasis [NCIt concept]
- Endocytotic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Lipid Transport [NCIt concept]
- Transport Process [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

Vous pouvez consulter :

recommendations
documents concerning education
documents for patients