" /> NPC Intracellular Cholesterol Transporter 1 - CISMeF





Preferred Label : NPC Intracellular Cholesterol Transporter 1;

NCIt synonyms : NPC1; Niemann-Pick C1 Protein;

NCIt definition : NPC intracellular cholesterol transporter 1 (1278 aa, 142 kDa) is encoded by the human NPC1 gene. This protein plays a role in the export of cholesterol from the endosomal/lysosomal compartment.;

NCIt note : NPC intracellular cholesterol transporter 1 acts as an endosomal entry receptor for ebolavirus. (UniProt); Cholesterol released from LDLs in late endosomes or lysosomes is transferred by NPC intracellular cholesterol transporter 2 to the cholesterol-binding pocket in the N-terminal domain of NPC intracellular cholesterol transporter 1. (UniProt);

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07/05/2025


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