NCIt definition : NPC intracellular cholesterol transporter 1 (1278 aa, 142 kDa) is encoded by the
human NPC1 gene. This protein plays a role in the export of cholesterol from the endosomal/lysosomal
compartment.;
NCIt note : NPC intracellular cholesterol transporter 1 acts as an endosomal entry receptor for
ebolavirus. (UniProt); Cholesterol released from LDLs in late endosomes or lysosomes is transferred by NPC
intracellular cholesterol transporter 2 to the cholesterol-binding pocket in the N-terminal
domain of NPC intracellular cholesterol transporter 1. (UniProt);