Myotonin-Protein Kinase

Preferred Label : Myotonin-Protein Kinase;

NCIt synonyms : DM1 Protein Kinase; EC 2.7.11.1; MT-PK; DMK; DMPK; DM-Kinase; Myotonic Dystrophy Protein Kinase;

NCIt definition : Myotonin-protein kinase (629 aa, 69 kDa) is encoded by the human DMPK gene. This protein is involved in the maintenance of skeletal muscle structure and function.;

NCIt note : Homodimerization of myotonin-protein kinase stimulates its activity and its substrates include the following: myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. (EntrezGene and UniProt);

Details

Origin ID

C200783;

UMLS CUI

C0216045;

OMIM relation
- Dystrophia myotonica protein kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Myotonin-Protein Kinase [MeSH Descriptor]
- Myotonin-Protein Kinase [MeSH concept]
gene_encodes_gene_product
- DMPK Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Muscle Contraction [NCIt concept]
- Myogenesis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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