" /> Type VII Collagen - CISMeF





Preferred Label : Type VII Collagen;

NCIt synonyms : Collagen VII;

NCIt related terms : Collagen 7; COLLAGEN TYPE VII; COLVII;

NCIt definition : Type VII collagen is a homotrimeric helical complex of the collagen alpha-1(VII) chain protein (COL7A1). This collagen is the major component of anchoring fibrils, which are specialized extracellular attachment complexes that form at the epithelium/mesenchyme interface in certain tissues. Following secretion of the triple-helical complex, two type VII collagen molecules align into an anti-parallel dimer, the carboxy-terminal non-collagenous domains (NC2) of both type VII collagen molecules are proteolytically removed and the anti-parallel dimer is stabilized by intermolecular disulfide bond formation. A large number of the stabilized anti-parallel dimers aggregate laterally to form anchoring fibrils.;

Alternative definition : CDISC: A member of the collagen superfamily with a Roman numeral designation of VII. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases bullous pemphigoid and epidermolysis bullosa acquisita.;

PubMed : 19945621;

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15/05/2024


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