" /> Chromodomain-Helicase-DNA-Binding Protein 3 - CISMeF





Preferred Label : Chromodomain-Helicase-DNA-Binding Protein 3;

NCIt synonyms : EC 3.6.4.12; hZFH; Chromodomain Helicase DNA Binding Protein 3; CHD3; ATP-Dependent Helicase CHD3; Mi-2 Autoantigen 240 kDa Protein; Zinc Finger Helicase; CHD-3; Chromodomain Helicase DNA-Binding Protein 3; Mi2-Alpha;

NCIt related terms : MI-2 ALPHA ANTIGEN; MI-2a; Dermatomyositis Autoantigen Mi-2 Alpha; MI-2 Alpha;

NCIt definition : Chromodomain-helicase-DNA-binding protein 3 (2000 aa, 227 kDa) is encoded by the human CHD3 gene. This protein is involved in chromatin remodeling, spindle organization during mitosis and transcriptional repression.;

Alternative definition : CDISC: The 220 kDa alpha isoform of the MI-2 antigen encoded by CHD3 gene, which is a helicase in the nucleosome remodeling-deacetylase complex involved in transcription regulation. It can be considered as an autoantigen and is commonly associated with the systemic autoimmune myopathy dermatomyositis.;

NCIt note : Chromodomain-helicase-DNA-binding protein 3 is part of the nucleosome remodeling and histone deacetylase (NuRD) complex and is an nuclear autoantigen in dermatomyositis.;

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29/04/2024


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