FAK Family Tyrosine Kinase

Preferred Label : FAK Family Tyrosine Kinase;

NCIt definition : Soluble cytoplasmic non-receptor FAK (Focal Adhesion Kinase) Family Tyrosine Kinases catalyze the phosphorylation of tyrosine residues in proteins with ATP or other nucleotides as phosphate donors. FAK is found in intracellular signaling focal adhesion complexes following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localizing FAK to focal adhesions.;

Details

Origin ID

C20037;

UMLS CUI

C1333531;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Defactinib [NCIt concept]
- Defactinib Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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