Preferred Label : Defactinib Hydrochloride;
NCIt synonyms : Benzamide, N-methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)-2-pyrazinyl)methyl)amino)-5-(trifluoromethyl)-2-pyrimidinyl)amino)-,
Hydrochloride (1:1);
NCIt definition : The hydrochloride salt form of defactinib, an orally bioavailable, small-molecule
focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic
activities. Defactinib inhibits FAK, which may prevent the integrin-mediated activation
of several downstream signal transduction pathways, including those involving RAS/MEK/ERK
and PI3K/Akt, thus inhibiting tumor cell migration, proliferation, survival, and tumor
angiogenesis. The tyrosine kinase FAK, a signal transducer for integrins, is normally
activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated
and constitutively activated in various tumor cell types.;
UNII : L2S469LM49;
InChIKey : RCHQNUQAHJNRBY-UHFFFAOYSA-N;
CAS number : 1073160-26-5;
NCI Metathesaurus CUI : CL512846;
Origin ID : C128039;
UMLS CUI : C4287800;
Semantic type(s)
- concept_is_in_subset
- has_target
