" /> SKI Oncoprotein - CISMeF





Preferred Label : SKI Oncoprotein;

NCIt synonyms : SK Oncogene; v-SKI Protein;

NCIt definition : The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN. SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB. The effects of SKI can be overcome by increased expression of SMAD3. (from OMIM 164780 and NCI);

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31/07/2025


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