SKI Oncoprotein

Preferred Label : SKI Oncoprotein;

NCIt synonyms : SK Oncogene; v-SKI Protein;

NCIt definition : The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN. SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB. The effects of SKI can be overcome by increased expression of SMAD3. (from OMIM 164780 and NCI);

Details

Origin ID

C19993;

UMLS CUI

C1335830;

Automatic exact mappings (from CISMeF team)
- Ski protooncogene [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Oncogene [NCIt concept]
- Oncogene SKI [NCIt concept]
gene_product_has_biochemical_function
- Nuclear Protein [NCIt concept]
- Transcription Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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