" /> Centromere Protein - CISMeF





Preferred Label : Centromere Protein;

NCIt synonyms : Centromeric Protein; CENP;

NCIt related terms : CENTROMERE;

NCIt definition : A protein that is a component of the kinetochore, a dynamic multiprotein molecular machine that assembles at the centromere of chromosomes. The kinetochore has two protein layers. Proteins in the inner kinetochore are involved in the formation of the specialized chromatin found in the centromere and persist throughout the cell cycle. Proteins in the outer kinetochore are only assembled in mitosis and meiosis, during which they bind to microtubules, mediate chromosome anchoring, control spindle formation, serve to verify the spindle checkpoint and drive chromosome segregation.;

Alternative definition : CDISC: Antigen(s) of the centromere protein family and are encoded by the CENP gene. They can be considered as autoantigens and are commonly associated with the autoimmune diseases Sjogren's syndrome, systemic sclerosis, and CREST syndrome.;

NCI Metathesaurus CUI : CL1914207;

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Keyword's position in hierarchy(ies) : arborescence

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09/05/2025


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