Major Centromere Autoantigen B

Preferred Label : Major Centromere Autoantigen B;

NCIt synonyms : Centromere Autoantigen B; Centromeric Protein B; Centromere Protein B; CENPB;

NCIt related terms : CENP-B; CENTROMERE B;

NCIt definition : Major centromere autoantigen B (599 aa, 65 kDa) is encoded by the human CENPB gene. This protein plays a role in the modulation of centromeric structures.;

Alternative definition : CDISC: An antigen of the centromere protein encoded by the CENPB gene, with a designation of B. It can be considered as an autoantigen and is commonly associated with the autoimmune disease CREST syndrome.;

NCIt note : Major centromere autoantigen B binds to a specific 17 bp sequence found in alpha-satellite (alphoid) DNA, called the CENP-B box.;

Details

Origin ID

C181695;

UMLS CUI

C1505574;

Automatic exact mappings (from CISMeF team)
- Centromere protein B [LOINC component]
- Centromeric protein b [OMIM gene]
- centromere protein B [MeSH concept]
- centromere protein B [HGNC gene]
- centromere protein b [MeSH Descriptor]
OMIM relation
- Centromeric protein b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CENPB protein, human [MeSH Supplementary Concept]
- CENPB protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- CENPB Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_biochemical_function
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Centromere Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Helix-Turn-Helix Motif [NCIt concept]
gene_product_is_element_in_pathway
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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