Thymic T-Cell Selection

Preferred Label : Thymic T-Cell Selection;

NCIt synonyms : Thymocyte Selection;

NCIt definition : Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus self-peptides in a process called positive selection under the influence of epithelial cells in the thymic cortex. Positively-selected thymic T cell precursors (thymocytes) then progress through a process called negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction where self-reactive, and potentially autoimmunity-inducing, thymocytes are deleted. Thymocytes simultaneously progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells.;

Details

Origin ID

C19064;

UMLS CUI

C1515433;

Currated CISMeF NLP mapping
- thymic T cell selection [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- thymic T cell selection [GO term]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_has_initiator_process
- Intercellular Communication Process [NCIt concept]
biological_process_has_result_anatomy
- T-Lymphocyte [NCIt concept]
biological_process_is_part_of_process
- Histogenic Process [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Immune System Process [NCIt concept]
biological_process_results_from_biological_process
- Anoikis [NCIt concept]
- Apoptosis [NCIt concept]
- Caspase-Dependent Apoptosis [NCIt concept]
- Caspase-Independent Apoptosis [NCIt concept]
- Leukocyte Apoptotic Process [NCIt concept]
- Lymphocyte Apoptotic Process [NCIt concept]
- Myeloid Cell Apoptotic Process [NCIt concept]
- Negative Regulation of Immune Cell Destruction [NCIt concept]
- Negative Regulation of Lymphocyte Apoptotic Process [NCIt concept]
- Negative Regulation of Myeloid Cell Apoptotic Process [NCIt concept]
process_includes_biological_process
- Clonal Regression [NCIt concept]
process_involves_gene
- T-Cell Receptor Alpha Locus [NCIt concept]

Keyword's position in hierarchy(ies) :

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