T-Cell Receptor Alpha Locus

Preferred Label : T-Cell Receptor Alpha Locus;

NCIt synonyms : TCRA; T-Cell Receptor Alpha Gene;

NCIt related terms : TRA;

NCIt definition : This region represents the germline organization of the T cell receptor alpha locus. The alpha locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the alpha chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink);

GenBank Accession Number : NG_001332;

Details

Origin ID

C26419;

UMLS CUI

C0524890;

Currated CISMeF NLP mapping
- Genes, T-Cell Receptor alpha [MeSH concept]
- genes, T-Cell receptor alpha [MeSH Descriptor]
HGNC gene
- T cell receptor alpha locus [HGNC gene]
OMIM relation
- T-cell receptor alpha chain constant region [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- Genes, T-Cell Receptor alpha [MeSH concept]
- T cell receptor alpha locus [HGNC gene]
- genes, T-Cell receptor alpha [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Reference Gene Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- T-Cell Receptor Alpha Chain [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 14q11.2 [NCIt concept]
gene_plays_role_in_process
- Cell Survival [NCIt concept]
- Immune System Process [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- T-Cell Activation [NCIt concept]
- Thymic T-Cell Selection [NCIt concept]
genetic_biomarker_related_to
- Cells with TRA and TRD Gene Rearrangements/Cells Counted in Blood or Tissue by FISH [NCIt concept]
- T-Cell Receptor Alpha-Beta [NCIt concept]
- TCR Alpha-Beta Positive [NCIt concept]
- TRA and TRD Gene Rearrangements [Interpretation] in Blood or Tissue by FISH Narrative [NCIt concept]
- TRA and TRD Gene Rearrangements [Presence] in Blood or Tissue by FISH [NCIt concept]

Keyword's position in hierarchy(ies) :

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