T-Cell Receptor Alpha-Beta

Preferred Label : T-Cell Receptor Alpha-Beta;

NCIt synonyms : TCR Alpha-Beta; T-Cell Receptor, Alpha-Beta; TCR Alpha/Beta; T-Cell Receptor Alpha/Beta; T-Cell Receptor Alpha Beta; Alpha-Beta TCR; Alpha-Beta-TCR; Alpha/Beta TCR;

NCIt definition : A heterodimeric complex comprised of the highly variable T-cell receptor (TCR) alpha and beta chain proteins, which are linked by interchain disulfide bonds. This membrane bound complex is expressed on the surface of most T-lymphocytes and is involved in the recognition of peptide antigens that are presented by major histocompatibility (MHC) proteins. The alpha/beta dimer is non-covalently associated with the CD3 complex, which promotes ligand-dependent signaling.;

Details

Origin ID

C17433;

UMLS CUI

C0085247;

Automatic exact mappings (from CISMeF team)
- TCR alpha beta [LOINC component]
- TCR alpha beta cells [LOINC component]
- receptors, antigen, T-Cell, alpha-beta [MeSH concept]
- receptors, antigen, t-cell, alpha-beta [MeSH Descriptor]
Currated CISMeF NLP mapping
- T-cell receptor alpha/beta (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- T-cell receptor alpha/beta (substance) [SNOMED CT concept]
- TCR alpha beta [LOINC component]
- receptors, antigen, T-Cell, alpha-beta [MeSH concept]
- receptors, antigen, t-cell, alpha-beta [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- T-Cell Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- T-Lymphocyte [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Immunoprotein [NCIt concept]
gene_product_plays_role_in_biological_process
- T-Cell Activation [NCIt concept]
has_gene_product_element
- T-Cell Receptor Alpha Chain [NCIt concept]
- T-Cell Receptor Beta Chain [NCIt concept]
related_to_genetic_biomarker
- T-Cell Receptor Alpha Locus [NCIt concept]
- T-Cell Receptor Beta Locus [NCIt concept]

Keyword's position in hierarchy(ies) :

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