Preferred Label : T-Cell Receptor Gene;
NCIt definition : The T-cell antigen receptors consist of a heterodimer of integral membrane glycoproteins.
Two distinct receptors exist, alpha/beta and gamma/delta. Alpha/beta receptors are
found on helper and cytotoxic T-cells and are specific for antigenic peptides presented
in association with MHC gene products. Gamma/delta receptors, found in association
with CD3, directly recognize proteins and non-proteinacious phospho-ligands. Alpha/beta
and gamma/delta are non-covalently associated with CD3-gamma, -delta, -epsilon, and
-zeta proteins, forming the TCR-CD3 complex, which activate MAPKs and JNK1 through
the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. The
genes for T-cell receptor subunits are encoded by distinct gene elements that are
assembled by somatic rearrangement during T-cell development. Translocations and inversions
of these loci are observed in human T-cell leukemias and lymphomas.;
Origin ID : C18017;
UMLS CUI : C0524889;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_found_in_organism
- gene_involved_in_molecular_abnormality
- gene_plays_role_in_process
