" /> T-Cell Receptor Beta Locus - CISMeF





Preferred Label : T-Cell Receptor Beta Locus;

NCIt synonyms : T-Cell Receptor Beta Gene; TCRB;

NCIt related terms : TRB;

NCIt definition : This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (from LocusLink);

GenBank Accession Number : U66059;

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12/05/2024


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