Tumor Necrosis Factor Ligand Superfamily Member 15

Preferred Label : Tumor Necrosis Factor Ligand Superfamily Member 15;

NCIt synonyms : Vascular Endothelial Growth Inhibitor; VEGI; TNFSF15; TNF Ligand-Related Molecule 1; VEG Inhibitor; TNF Superfamily Ligand TL1A;

NCIt definition : Tumor necrosis factor ligand superfamily member 15 (251 aa, 28 kDa) is encoded by the human TNFSF15 gene. This protein plays a role in both the inhibition of angiogenesis and the induction of apoptosis.;

NCIt note : Tumor necrosis factor ligand superfamily member 15 is a TNF-related type II transmembrane protein, with an extracellular C-terminus, a single transmembrane domain, and a short cytoplasmic tail. Soluble forms of the protein markedly reduce vascularization and inhibits the growth of aortic endothelial cells and colon carcinomas.;

Details

Origin ID

C18289;

UMLS CUI

C0762871;

Currated CISMeF NLP mapping
- tumor necrosis factor ligand superfamily member 15 [MeSH Descriptor]
- tumor necrosis factor ligand superfamily member 15 [MeSH concept]
OMIM relation
- Tumor necrosis factor ligand superfamily, member 15 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TNFSF15 protein, human [MeSH concept]
- TNFSF15 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- TNFSF15 Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Death Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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