G Protein-Coupled Receptor

Preferred Label : G Protein-Coupled Receptor;

NCIt synonyms : G-Protein Coupled Receptor; G Protein-Complex Receptor; GPCR; G Protein-Complex Receptors; G Protein Coupled Receptor;

NCIt definition : Cell surface receptors that are coupled to G-proteins (GTP-binding protein). G-protein coupled receptors are thought to have seven membrane spanning domains and have been divided into 2 subclasses: those in which the binding site is in the extracellular domain for example receptors for glycoprotein hormones, such as thyroid stimulating hormone (TSH) and follicle-stimulating hormone (FSH) and those in which the ligand binding site is likely to be in the plane of the 7 transmembrane domains for example rhodopsin and receptors for small neurotransmitters and hormones for example muscarinic acetylcholine receptor.;

Details

Origin ID

C18239;

UMLS CUI

C0682972;

Biochemical function of gene products
- Adrenergic Receptor [NCIt concept]
- Melatonin Receptor [NCIt concept]
- Purinergic P1 Receptor [NCIt concept]
- Somatostatin Receptor [NCIt concept]
Currated CISMeF NLP mapping
- receptors, G-Protein-Coupled [MeSH concept]
- receptors, g-protein-coupled [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptors, G-Protein-Coupled [MeSH concept]
- receptors, g-protein-coupled [MeSH Descriptor]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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