Leukocyte-Associated Immunoglobulin-Like Receptor 1

Preferred Label : Leukocyte-Associated Immunoglobulin-Like Receptor 1;

NCIt synonyms : LAIR1; CD305; Leukocyte Associated Immunoglobulin Like Receptor 1; Leukocyte-Associated Ig-Like Receptor 1; LAIR-1; CD305 Antigen; hLAIR1;

NCIt definition : Leukocyte-associated immunoglobulin-like receptor 1 (287 aa, 31 kDa) is encoded by the human LAIR1 gene. This protein is involved in immune tolerance to self-expressed antigens and binding to cell-associated collagen alpha-1(XVII) chain.;

NCI Metathesaurus CUI : CL1770628;

Details

Origin ID

C182136;

UMLS CUI

C5575597;

Automatic exact mappings (from CISMeF team)
- Leukocyte-associated immunoglobulin-like receptor 1 [OMIM gene]
- leukocyte associated immunoglobulin like receptor 1 [HGNC gene]
- leukocyte-associated immunoglobulin-like receptor 1 [MeSH Supplementary Concept]
- leukocyte-associated immunoglobulin-like receptor 1 [MeSH concept]
OMIM relation
- Leukocyte-associated immunoglobulin-like receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- LAIR1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- B-Lymphocyte [NCIt concept]
- Dendritic Cell [NCIt concept]
- Monocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- ITIM [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Intercellular Communication Induction [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Cytolytic Process [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Anti-LAIR1 Monoclonal Antibody NC525 [NCIt concept]
- Anti-LAIR1 Monoclonal Antibody NGM438 [NCIt concept]
- LAIR-2 Fusion Protein NC410 [NCIt concept]

Keyword's position in hierarchy(ies) :

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